📃 Paper Title: 2-18fluoro-deoxy-D-glucose Positron Emission Tomography Is a Reliable Predictor for Viable Tumor in Postchemotherapy Seminoma: An Update of the Prospective Multicentric SEMPET Trial
🧍 Author: De Santis
🕒 Year: 2004
📚 Journal: Journal of Clinical Oncology
🌎 Country: Austria
ㅤContext to the study:
Can you tell me about a study that demonstrated the predictive value of 2-18 FDG PET (2-18 fluoro-deoxy-D-glucose) positron emission tomography in detecting residual seminoma post-chemotherapy
ㅤ✅ Take-home message of study:
2-18 FDG PET (2-18 fluoro-deoxy-D-glucose) positron emission tomography has a high specificity (100%) and positive predictive value (100%) with a good sensitivity (80%) and negative predictive value (96%) in detecting residual seminoma post-treatment with chemotherapy compared to conventional CT scanning and may save patients unnecessary surgery to remove masses with no presence of viable tumour.
ㅤ Prospective, multicentre
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Study participants:
Study Size:
51 patients enrolled from 7 centres with a total of 56 PET scans available for review.
11 patients had surgery to resect the residual mass (7 >3cm and 4 ≤3cm)
Viable tumour was found in 3 out of 4 >3cm lesions. The rest showed only fibrosis.
The remaining patients were followed-up clinically.
Inclusion criteria:
Men with metastatic pure testicular or extragonadal seminomas who had negative tumour markers on completion of platinum-based chemotherapy or salvage chemotherapy who showed a residual mass of at least 1cm on post-treatment CT scanning.
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Key study outcomes:
During follow-up, 8 positive PET scans were identified and these patients underwent biopsy which confirmed the presence residual tumour on histology.
Of the remaining 48 negative PET scans, two lesions ≤3cm were negative but harboured viable tumour on histology.
On the 56 original PET scans, 19 lesions > 3 cm (100%) and 35 of 37 (95%) lesions ≤ 3 cm were correctly predicted to be positive for residual disease by FDG PET.
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Study Limitations:
Small patient cohort size
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